Pharmacology

Pharmacodynamics

Benzydamine is a non-steroidal anti-inflammatory drug, belongs to the group of indazoles. It has anti-inflammatory and local analgesic effects, has antiseptic action against a wide range of microorganisms, restores microcirculation. The mode of action of the product is associated with stabilization of cell membranes and inhibition of prostaglandin synthesis.

Benzydamine has antibacterial and specific antimicrobial effect due to rapid penetration through the membranes of microorganisms with subsequent damage to cellular structures, disruption of metabolic processes and cell lysosomes.

It has antifungal action against Candida albicans. It causes structural modifications of the cell wall of fungi and their metabolic chains, thus preventing their reproduction, which was the basis for the use of benzydamine in inflammatory processes in the oral cavity, including infectious etiology.

Pharmacokinetics

When applied topically, the product is well absorbed through mucous membranes and penetrates into inflamed tissues, it is found in blood plasma in an amount insufficient to produce systemic effects.

Excretion of the product occurs mainly by kidneys, in the form of inactive metabolites or conjugation products.

INDICATIONS FOR USE

Symptomatic treatment of pain syndrome of inflammatory diseases of the oral cavity and ENT-organs (various etiologies):

• gingivitis, glossitis, paradontosis, stomatitis (including after radiotherapy and chemotherapy)
• pharyngitis, laryngitis, tonsillitis
• oral candidiasis (as part of combination therapy)
• calculous sialadenitis
• after surgical interventions and trauma (tonsillectomy, jaw fractures)
• after dental treatment and extraction

In infectious and inflammatory diseases requiring systemic treatment, it is necessary to use the product as part of combination therapy.

CONTRAINDICATIONS

• - hypersensitivity to benzydamine or other ingredients of the product;
• - children under 12 years old.

Should be taken with caution

Hypersensitivity to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs, bronchial asthma (including history).

Administration during pregnancy and breast-feeding period

It should not be used during pregnancy and breast-feeding period.

Posology and administration

Topical, after meals. Adults (including elderly patients) and children aged 12 and older use 15 mL of the product (measuring cup is enclosed) 2–3 times a day for gargle. After gargling the solution should be spit out. If burning sensation occurs when using undiluted solution, the solution should be diluted (for dilution add 15 mL of water to the measuring cup). Do not exceed the recommended dose.

The duration of treatment is 7 days; if after 7 days of treatment there is no improvement or new symptoms appear, it is necessary to consult a healthcare professional.

Use the product only according to the route of administration and in the doses indicated in the instruction for use. If necessary, consult a healthcare professional before using the product.